The nematode Caenorhabditis elegans is emerging as a facile and economical model host for the study of evolutionarily conserved mechanisms of microbial pathogenesis and innate immunity. A rapidly growing number of human and animal microbial pathogens have been shown to injure and kill nematodes. In many cases, microbial genes known to be important for full virulence in mammalian models have been shown to be similarly required for maximum pathogenicity in nematodes. C. elegans has been used in mutation-based screening systems to identify novel virulence-related microbial genes and immune-related host genes, many of which have been validated in mammalian models of disease. C. elegans-based pathogenesis systems hold the potential to simultaneously explore the molecular genetic determinants of both pathogen virulence and host defense.

译文

线虫秀丽隐杆线虫正在成为研究微生物发病机理和先天免疫的进化保守机制的简便而经济的模型宿主。越来越多的人类和动物微生物病原体已被证明会伤害和杀死线虫。在许多情况下,已知对哺乳动物模型中的完全毒力很重要的微生物基因已被证明是线虫最大致病性所必需的。秀丽隐杆线虫已被用于基于突变的筛选系统,以鉴定新的毒力相关微生物基因和免疫相关宿主基因,其中许多已在哺乳动物疾病模型中得到验证。基于秀丽隐杆线虫的发病机制系统具有同时探索病原体毒力和宿主防御的分子遗传决定因素的潜力。

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