The inflammatory component associated with blackening and subsequent regression of plantar warts has been little appreciated in the literature. Two patients with plantar warts in whom one of the warts showed prominent, clinically evident inflammation were observed. Blackening and subsequent regression of all plantar warts then occurred. In one patient, microscopic examination of biopsy specimens of two lesions that were taken within 24 and 72 hours, respectively, after they had turned black demonstrated the following histologic findingsblood clots and hemorrhage in the stratum corneum, degeneration and necrosis of epidermal cells, eosinophilic cytoplasmic masses within degenerating epidermal cells, thrombosis of superficial and deeper dermal blood vessels, a mononuclear cell infiltrate in and around dermal blood vessels, and a mixed polymorphonuclear and lymphocytic infiltration in the areas of hemorrhage and degenerating epidermis. This constellation of histopathologic changes suggests that involution was in progress long before blackening of the warts occurred.

译文

与变黑和随后的足底疣消退有关的炎症成分在文献中很少得到重视。观察到两名足底疣患者,其中一个疣表现出明显的临床明显炎症。然后发生所有足底疣的黑化和随后的消退。在一名患者中,分别在变黑后的24和72小时内对两个病变的活检标本进行显微镜检查,结果显示以下组织学发现角质层的血凝块和出血,表皮细胞的变性和坏死,退化的表皮细胞内的嗜酸性细胞质团块,浅表和深层真皮血管的血栓形成,单个核细胞在真皮血管内及其周围浸润,并在出血和表皮退化区域混合多形核和淋巴细胞浸润。这种组织病理学变化的星座表明,在疣变黑之前很久就在进行中。

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