To evaluate the effectiveness of a cytological screening to prevent invasive cervical cancer in the province of Trento, a northern Italian area where a population-based cancer registry is active. The history of Pap test was evaluated through a case-control study in 61 population-based invasive cervical cancer patients, incident during 1995-2000, and in 244 age-matched (between 25 and 75 years old) controls. Women who had at least one Pap test had a reduced risk of invasive carcinoma of 80% (odds ratio=0.20; 95% confidence intervals 0.10-0.40). The protection of a previous Pap test for both squamous cell carcinoma (odds ratio=0.23; 95% confidence intervals 0.09-0.58) and adenocarcinoma (odds ratio=0.24; 95% confidence intervals 0.07-0.78) was similar. The overall protective effect of the Pap test was not seen among younger women (<40 years). The protective effect of the Pap test seems to be stronger for shorter intervals. Our study confirms that Pap-test screening, particularly in middle-aged and older women, is an effective public health intervention with encouraging results also for the prevention of cervical adenocarcinoma.

译文

评估细胞学筛查在意大利北部特伦托省预防浸润性宫颈癌的有效性,特伦托省是一个基于人群的癌症登记处。通过病例对照研究评估了61例基于人群的浸润性宫颈癌患者的Pap测试史,这些患者在1995-2000期间发生,并且在244年龄匹配 (25至75岁) 的对照中。至少进行了一次巴氏试验的女性患80% 浸润性癌的风险降低 (比值比 = 0.20; 95% 置信区间0.10-0.40)。先前的Pap测试对鳞状细胞癌 (优势比 = 0.23; 95% 置信区间0.09-0.58) 和腺癌 (优势比 = 0.24; 95% 置信区间0.07-0.78) 的保护相似。巴氏试验的总体保护作用在年轻女性 (<40岁) 中未见。对于较短的间隔,巴氏试验的保护作用似乎更强。我们的研究证实,巴氏试验筛查 (尤其是中老年妇女) 是一种有效的公共卫生干预措施,在预防宫颈腺癌方面也取得了令人鼓舞的结果。

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