Tuberculosis (TB) is an intricate infectious disease that causes a large number of deaths in the population. Interleukin (IL)-6 and IL-13 play functional roles in host resistance to Mycobacterium tuberculosis infection. Our aim in this study was to explore the association of IL-6 and IL-13 polymorphisms with TB susceptibility in the Western Chinese Han population. The case and control groups comprised 900 TB patients and 1534 healthy controls, respectively, and four single-nucleotide polymorphisms (SNPs) were genotyped in IL-6 and five SNPs in IL-13 through the improved multiplex ligation detection reaction method. We found no genetic variants in the IL-6 or IL-13 genes that were related to TB susceptibility in the analysis of alleles, genotypes, genetic models, and TB clinical subtypes, except for a trend toward low pulmonary tuberculosis and extrapulmonary tuberculosis susceptibility for the SNPs rs1295686 and rs20541. Our study did not find a link between IL-6 and IL-13 polymorphisms and TB susceptibility in the Western Chinese Han population. Therefore, our present data revealed the challenge of applying IL-6 and IL-13 SNPs as genetic markers for TB and that increased sample sizes and additional races are needed for further studies.

译文

结核病 (TB) 是一种复杂的传染病,导致人口大量死亡。白细胞介素 (IL)-6和IL-13在宿主对结核分枝杆菌感染的耐药性中起着重要作用。我们在这项研究中的目的是探讨IL-6和IL-13多态性与中国西部汉族人群结核病易感性的关系。病例组和对照组分别包括900例结核病患者和1534例健康对照者,通过改进的多重连接检测反应方法对4个单核苷酸多态性 (SNPs) 和5个IL-13进行IL-6基因分型。在等位基因,基因型,遗传模型和结核病临床亚型的分析中,我们没有发现与结核病易感性相关的IL-6或IL-13基因中的遗传变异,除了SNPs rs1295686和rs20541的低肺结核和肺外结核易感性趋势。我们的研究没有发现中国西部汉族人群IL-6和IL-13多态性与结核病易感性之间的联系。因此,我们目前的数据揭示了应用IL-6和IL-13 snp作为结核病遗传标记的挑战,并且需要增加样本量和其他种族来进行进一步的研究。

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