Rifampicin is a key component of treatment for tuberculosis and its efficacy is determined by the blood levels attained after therapeutic doses. However, there is a high variability of rifampicin blood levels that is related to both the patient and the formulation used. To date, the effect of diabetes mellitus on the plasma levels of rifampicin was low exploited, which could be relevant either by the significant increase of the comorbidity worldwide as by the probable influence of diabetes on the rifampicin exposure. The study aims to evaluate whether diabetes mellitus contribute to the variation of the maximum concentration of rifampicin in patients with tuberculosis treated with a daily dose of 10mg/kg. Rifampicin and glycated hemoglobin were measured by high-performance liquid chromatography, and blood glucose by spectrophotometry. A total of 62 male patients were included in the study, and 26 presented diabetes mellitus. Rifampicin plasma levels in 2-h plasma samples collected at day 61 ranged from 3μg/mL to 14.2μg/mL. Drugs levels were similar between diabetic and non-diabetic patients and were not correlated with blood glucose and glycated hemoglobin. Moreover, a high percentage of patients in both groups presented low levels of rifampicin.

译文

利福平是结核病治疗的关键成分,其疗效取决于治疗剂量后达到的血液水平。然而,利福平血液水平的高度变异性与患者和所用制剂均有关。迄今为止,糖尿病对利福平血浆水平的影响很低,这可能与世界范围内合并症的显着增加以及糖尿病对利福平暴露的可能影响有关。该研究旨在评估每日剂量为10mg/kg的结核病患者中,糖尿病是否会导致利福平最大浓度的变化。用高效液相色谱法测定利福平和糖化血红蛋白,用分光光度法测定血糖。该研究共纳入62名男性患者,其中26名患有糖尿病。在第61天收集的2小时血浆样品中的利福平血浆水平范围为3 μ g/mL至14.2 μ g/mL。糖尿病和非糖尿病患者的药物水平相似,并且与血糖和糖化血红蛋白无关。此外,两组患者的利福平水平均较低。

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