Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a nonionic, broad spectrum, antimicrobial agent that, because of its favorable safety profile, has been incorporated into a variety of many personal care products, including deodorant soaps, underarm deodorants, shower gels, and health care personnel handwashes. Triclosan exhibits a moderate degree of substantivity to the skin, and, in many products, it imparts a remnant antimicrobial effect. Although direct contact with the material under exaggerated exposure conditions causes dermal irritation in laboratory animals, it has only rarely been associated with skin irritation or sensitization in human being in formulated products. Acute, subacute/subchronic, and chronic toxicity profiles have been established to determine that triclosan is neither an acute oral toxicant nor that it acts as a carcinogen, mutagen, or teratogen. A new application for triclosan is in oral dentifrices for plaque control. Currently under investigation in the United States, it is approved for oral care application in Canada and many European countries.

译文

三氯生 (2,4,4 '-trichloro-2'-羟基二苯醚) 是一种非离子、广谱的抗微生物剂,由于其良好的安全性,已被掺入多种个人护理产品中,包括除臭肥皂、腋下除臭剂、淋浴凝胶和卫生保健人员洗手。三氯生对皮肤表现出中等程度的直接性,并且在许多产品中,它具有残留的抗菌作用。尽管在夸张的暴露条件下直接与材料接触会在实验动物中引起皮肤刺激,但在配方产品中,它很少与人类的皮肤刺激或致敏有关。已经建立了急性,亚急性/亚慢性和慢性毒性特征,以确定三氯生既不是急性口服毒物,也不是致癌物,诱变剂或致畸剂。三氯生的一种新应用是在口腔洁齿剂中控制牙菌斑。目前在美国正在调查中,它已在加拿大和许多欧洲国家批准用于口腔护理应用。

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