Recently, several emerging pollutants, including Personal Care Products (PCPs), have been detected in aquatic ecosystems, in the ng/L or µg/L range. Available toxicological data is limited, and, for certain PCPs, evidence indicates a potential risk for the environment. Hence, there is an urgent need to gather ecotoxicological data on PCPs as a proxy to improve risk assessment. Here, the toxicity of three different PCPs (4-Methylbenzylidene Camphor (4-MBC), propylparaben and triclocarban) was tested using embryo bioassays with Danio rerio (zebrafish) and Paracentrotus lividus (sea urchin). The No Observed Effect Concentration (NOEC) for triclocarban was 0.256 µg/L for sea urchin and 100 µg/L for zebrafish, whereas NOEC for 4-MBC was 0.32 µg/L for sea urchin and 50 µg/L for zebrafish. Both PCPs impacted embryo development at environmentally relevant concentrations. In comparison with triclocarban and 4-MBC, propylparaben was less toxic for both sea urchin (NOEC = 160 µg/L) and zebrafish (NOEC = 1000 µg/L). Overall, this study further demonstrates the sensitivity of embryo bioassays as a high-throughput approach for testing the toxicity of emerging pollutants.

译文

最近,在水生生态系统中检测到几种新出现的污染物,包括个人护理产品 (pcp),范围为ng/L或 µ g/L。可用的毒理学数据有限,对于某些pcp,证据表明对环境有潜在风险。因此,迫切需要收集有关PCPs的生态毒理学数据作为代理,以改善风险评估。在这里,使用Danio rerio (斑马鱼) 和Paracentrotus lividus (海胆) 的胚胎生物测定法测试了三种不同pcp (4-甲基苄叉樟脑 (4-MBC),对羟基丙酯和三氯卡班) 的毒性。三氯卡班的No观察效果浓度 (NOEC) 对海胆为0.256 µ g/L,对斑马鱼为100 µ g/L,而对4-mbc的NOEC对海胆为0.32 µ g/L,对斑马鱼为50 µ g/L。两种pcp均在与环境相关的浓度下影响胚胎发育。与三氯卡班和4-MBC相比,对羟基苯甲酸丙酯对海胆 (NOEC = 160 µ g/L) 和斑马鱼 (NOEC = 1000 µ g/L) 的毒性较低。总体而言,这项研究进一步证明了胚胎生物测定作为测试新兴污染物毒性的高通量方法的敏感性。

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