Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposure. After exposure to 0.3, 30, and 300 μg/L TCC from 4-hour postfertilization (hpf) to 120 hpf, we observed that TCC exposure significantly increased the mortality and malformation, delayed hatching, and reduced body length. Exposure to TCC also affected the heart rate and expressions of cardiac development-related genes in zebrafish embryos. In addition, TCC exposure altered the expressions of the genes involved in hormonal pathways, indicating its endocrine disrupting effects. In sum, our data highlight the impact of TCC on embryo development and its interference with the hormone system of zebrafish.

译文

三氯卡班 (TCC) 在个人护理产品中用作抗菌剂,已在水生生态系统中广泛检测到。然而,TCC暴露对胚胎发育的影响仍然难以捉摸。在这里,通过使用斑马鱼胚胎,我们旨在了解TCC暴露引起的发育缺陷。从受精后4小时 (hpf) 到120 hpf暴露于0.3、30和300  μ g/L的TCC后,我们观察到TCC暴露显着增加了死亡率和畸形,延迟孵化并缩短了体长。TCC暴露还会影响斑马鱼胚胎的心率和心脏发育相关基因的表达。此外,TCC暴露改变了激素途径中涉及的基因的表达,表明其内分泌干扰作用。总之,我们的数据强调了TCC对胚胎发育的影响及其对斑马鱼激素系统的干扰。

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