Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription.

译文

河马信号控制最终影响器官发生和体内平衡的细胞过程。因此,当信号解除管制时,包括癌症在内的疾病状态可能会出现。主要途径转导子Yap和Taz需要辅因子来赋予靶基因转录控制。对Yap/Taz介导的表观遗传修饰的研究表明,它们与染色质重塑复合物蛋白的关联是改变染色质结构的一种手段,因此影响了靶基因的可及性和活性。具体而言,已发现Yap/Taz与GAGA,Ncoa6,介体,开关/蔗糖不可发酵 (SWI/SNF) 以及核小体重塑和脱乙酰酶 (NuRD) 染色质重塑复合物的因子相关,以改变目标基因的可及性。这篇综述强调了Yap/Taz与其他因素合作以修饰特定基因座处的DNA包装以激活或抑制靶基因转录的不同机制。

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