p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as "the guardian of the genome" and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of developmental and regenerative physiological processes but if deregulated can induce cell transformation and cancer progression. The p53 and Hippo pathways exert a plethora of fine-tuned functions that can apparently be in contrast with each other. In this review, we propose that the p53 status can affect the Hippo pathway function by switching its outputs from tumor suppressor to oncogenic activities. In detail, we discuss: (a) the oncogenic role of the protein complex mutant p53/YAP; (b) TAZ oncogenic activation mediated by mutant p53;

译文

p53蛋白是一种众所周知的肿瘤抑制因子,可调节细胞内稳态。由于p53具有多种关键功能,因此被称为 “基因组的守护者”,TP53编码蛋白序列中的功能丧失或功能突变的获得都与癌症的发生和发展有关。Hippo途径是发育和再生生理过程的关键调节剂,但如果放松管制,则可以诱导细胞转化和癌症进展。p53和Hippo途径发挥了许多微调功能,显然可以相互对比。在这篇综述中,我们提出p53状态可以通过将其输出从肿瘤抑制因子转换为致癌活性来影响Hippo途径的功能。详细地,我们讨论了 :( a) 蛋白质复合物突变体p53/YAP的致癌作用; (b) 突变p53介导的TAZ致癌激活;

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