Monomeric G-proteins, also referred to as small GTPases, function as biological hubs being activated by extracellular stimuli and regulate downstream signalling events, which result in different cellular responses. The importance of these mechanisms is mirrored by the fact that several pathological conditions, including allergic asthma, are associated with derailed GTPases signalling. For this reason attention has been focused on the role of monomeric G-proteins and their effectors in airway (patho)physiology. In this article we review our current knowledge on the regulation and functions of Ras and Rho GTPase signalling under physiological and pathophysiological conditions in the pulmonary system. Based on recent findings concerning novel regulatory proteins for Ras family members, we further discuss potential future directions for therapeutical interventions in asthma.

译文

单体g蛋白,也称为小gtp酶,充当被细胞外刺激激活的生物枢纽,并调节下游信号传导事件,从而导致不同的细胞反应。这些机制的重要性反映在以下事实中: 包括过敏性哮喘在内的几种病理状况与脱轨的GTPases信号有关。由于这个原因,人们的注意力集中在单体g蛋白及其效应子在气道 (病理) 生理学中的作用。在这篇文章中,我们回顾了我们目前关于Ras和Rho GTPase信号在肺系统的生理和病理生理条件下的调节和功能的知识。基于有关新颖的最新发现ras家族成员的调节蛋白,我们进一步讨论了哮喘治疗干预的潜在未来方向。

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