Oxidation of low-density lipoprotein (LDL) is one of the major factors in atherogenic process. Trapped oxidized LDL (Ox-LDL) in the subendothelial matrix is taken up by macrophage and leads to foam cell generation creating the first step in atherosclerosis development. Many researchers have studied LDL oxidation using in vitro cell-induced LDL oxidation model. The present study provides a kinetic model for LDL oxidation in intima layer that can be used in modeling of atherosclerotic lesions development. This is accomplished by considering lipid peroxidation kinetic in LDL through a system of elementary reactions. In comparison, characteristics of our proposed kinetic model are consistent with the results of previous experimental models from other researches. Furthermore, our proposed LDL oxidation model is added to the mass transfer equation in order to predict the LDL concentration distribution in intima layer which is usually difficult to measure experimentally. According to the results, LDL oxidation kinetic constant is an important parameter that affects LDL concentration in intima layer so that existence of antioxidants that is responsible for the reduction of initiating rates and prevention of radical formations, have increased the concentration of LDL in intima by reducing the LDL oxidation rate.

译文

低密度脂蛋白 (LDL) 的氧化是动脉粥样硬化过程的主要因素之一。内皮下基质中捕获的氧化LDL (Ox-LDL) 被巨噬细胞摄取,并导致泡沫细胞的产生,从而形成动脉粥样硬化发展的第一步。许多研究人员使用体外细胞诱导的LDL氧化模型研究了LDL氧化。本研究提供了内膜层LDL氧化的动力学模型,可用于模拟动脉粥样硬化病变的发展。这是通过通过基本反应系统考虑LDL中的脂质过氧化动力学来实现的。相比之下,我们提出的动力学模型的特征与其他研究的先前实验模型的结果一致。此外,我们提出的LDL氧化模型被添加到传质方程中,以预测内膜层中的LDL浓度分布,这通常很难通过实验进行测量。根据结果,LDL氧化动力学常数是影响内膜层中LDL浓度的重要参数,因此抗氧化剂的存在负责降低起始速率和防止自由基形成,通过降低LDL氧化速率来增加内膜中LDL的浓度。

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