Pharmacotherapies for the behavioural and psychological symptoms of dementia are limited; novel agents for the symptoms are still needed. Herein, we report the case of an 80-year-old male patient with Alzheimer's disease whose severe agitation, insomnia and sexual delusions were successfully treated with a traditional natural Japanese (Kampo) medicine, keishi-ka-ryukotsu-borei-to. We found that administrating keishi-ka-ryukotsu-borei-to increased his serum luteinizing hormone level, which could be inversely associated with his behavioural and psychological symptoms. This report suggests that keishi-ka-ryukotsu-borei-to is a possible alternative treatment for the behavioural and psychological symptoms of dementia, especially sexual delusions.

译文

针对痴呆症的行为和心理症状的药物疗法有限; 仍然需要针对这些症状的新型药物。在此,我们报告了一名80岁的男性阿尔茨海默氏病患者,其严重的躁动,失眠和性妄想已成功地用传统的天然日本 (Kampo) 药物keishi-ka-ryukotsu-borei-too治疗。我们发现,服用keishi-ka-ryukotsu-borei-会增加他的血清黄体生成激素水平,这可能与他的行为和心理症状成反比。该报告表明,keishi-ka-ryukotsu-borei-too可能是治疗痴呆症的行为和心理症状,尤其是性妄想的替代疗法。

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