Eradication or suppression of pathogens is a major goal in periodontal therapy. Due to the increase in antibiotic resistance, the need of new disinfection therapies is raising. Photodynamic therapy (PDT) has demonstrated anti-infective potential. No data are available on the use of light-emitting diode (LED) lights as the light source in PDT. The aim of this study was to investigate the microbiological and clinical adjunctive outcome of a new photodynamic LED device, compared to scaling and root planing in periodontitis patients in maintenance [supportive periodontal therapy (SPT)]. In this masked, split-mouth design study, 30 treated chronic periodontitis subjects (mean age, 46.2 years; 13 males) in SPT were included. Two residual interdental sites with probing pocket depth (PPD) ≥ 5 mm in two opposite quadrants, with positive bleeding on probing (BOP) and comparable periodontal breakdown, were selected. PPD, BOP and subgingival microbiological samples for real-time PCR analysis (Carpegen® PerioDiagnostics, Carpegen GmbH, Münster, Germany) were recorded at baseline and 1 week after treatment. Scaling and root planing was performed under local anesthesia. Randomly one of the sites was selected to receive adjunctive photodynamic therapy by inserting a photosensitizer (toluidine blue O solution) and exposing it to a LED light in the red spectrum (Fotosan, CMS Dental, Copenhagen, Denmark), according to the manufacturer's instructions. After 1 week, 73 % of the control sites and 27 % of the test sites were still BOP+. These differences compared to baseline values and in-between groups were statistically significantly different (p < 0.001). Mean PPD decreased from 5.47 mm (±0.68) to 4.73 mm (±0.74, p < 0.001) in control sites and from 5.63 mm (±0.85) to 4.43 mm (±1.25, p < 0.001, test vs control p = 0.01) in the test group. Microbiologically, higher reductions of relative proportions of red complex bacteria were observed in test sites (68.1 vs. 4.1 %; p = 0.01). This study showed that adjunctive photodynamic treatment by LED light may enhance short-term clinical and microbiological outcome in periodontitis subjects in SPT.

译文

根除或抑制病原体是牙周治疗的主要目标。由于抗生素耐药性的增加,新的消毒疗法的需求正在增加。光动力疗法 (PDT) 已显示出抗感染潜力。没有关于在PDT中使用发光二极管 (LED) 灯作为光源的数据。这项研究的目的是研究一种新型光动力LED设备的微生物学和临床辅助结果,与牙周炎患者在维持 [支持性牙周治疗 (SPT)] 中的牙周炎患者进行结垢和牙根平整相比。在这项蒙面的裂口设计研究中,包括30名接受治疗的SPT慢性牙周炎受试者 (平均年龄46.2岁; 13名男性)。选择了两个相对象限中探查袋深度 (PPD) ≥   5毫米的两个残留齿间部位,探查出血 (BOP) 阳性,牙周分解相当。用于实时PCR分析的PPD,BOP和龈下微生物样品 (Carpegen®在基线和治疗后1周记录PerioDiagnostics,Carpegen GmbH,m ü nster,德国)。在局部麻醉下进行了缩放和根刨除。根据制造商的说明,通过插入光敏剂 (甲苯胺蓝O溶液) 并将其暴露于红色光谱的LED光 (Fotosan,CMS Dental,哥本哈根,丹麦),随机选择其中一个部位接受辅助光动力疗法。1周后,73% 对照部位和27% 试验部位仍为BOP +。这些差异与基线值和组间比较在统计学上有显著差异 (p <0.001)。在对照组中,平均PPD从5.47毫米 (± 0.68) 降至4.73毫米 (± 0.74,p <0.001),在试验组中从5.63毫米 (± 0.85) 降至4.43毫米 (± 1.25,p <0.001,测试vs对照p = 0.01)。在微生物学上,在测试部位观察到红色复合细菌相对比例的较高降低 (68.1对4.1%; p = 0.01)。这项研究表明,通过LED光辅助光动力治疗可能会增强SPT牙周炎受试者的短期临床和微生物学结果。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录