To investigate brain correlates of cognitive function in obsessive-compulsive disorder (OCD), event-related potentials (ERPs) were recorded in a group of thirteen unmedicated OCD patients and thirteen normal controls for verbal auditory stimuli in an oddball paradigm. The patients showed longer latencies of the N1 and P2, shorter latency of the P3, and reduced amplitude of the N2. These results suggest that OCDs stress the speed of task-dependent processes (i.e., by showing shorter N2 and P3 latencies) and have impairment of task-independent ones (i.e., by showing longer N1 and P2 latencies and reduced N2 amplitude). The components were more positive in the left hemisphere in OCDs and in the right hemisphere in normal controls. Future responders to treatment had significantly reduced N2 and enhanced P3 amplitudes relative to future nonresponders. So ERPs might provide psychophysiological profiles in OCDs with clinical and pharmacological implications.

译文

为了研究强迫症 (OCD) 中认知功能的脑相关性,在一组13名未服药的OCD患者和13名正常对照中记录了事件相关电位 (erp)。患者显示N1和P2的潜伏期更长,P3的潜伏期更短,n2的振幅降低。这些结果表明,ocd强调了任务相关过程的速度 (即,通过显示较短的N2和P3潜伏期),并损害了与任务无关的过程 (即,通过显示较长的N1和P2潜伏期以及降低的N2振幅)。在ocd的左半球和正常对照组的右半球中,这些成分更为阳性。与未来的无反应者相比,未来对治疗的反应者显着降低了N2,并增强了P3幅度。因此,ERPs可能会在OCDs中提供具有临床和药理意义的心理生理特征。

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