In the present work, a nanocomposite hydrogel wound dressing was prepared on the basis of poly(vinyl alcohol) using organically-modified montmorillonite as nanoclay by the freezing-thawing cyclic method. In vivo assays were performed to evaluate its performance as an applicable wound dressing on animals. It showed an improved healing process for wounds covered by the prepared nanocomposite hydrogel compared with control wounds covered by sterile gauze. Significant improvements, such as better creation of moist surfaces on the wound with less scar formation, shorter duration of healing operation and better closing of the wound edges with enhanced tensile properties of the healed wound, i.e., tensile strength and elongation-at-break, were observed using the prepared nanocomposite hydrogel in comparison to the sterile gauze. An in vitro cytotoxic assay was also utilized to determine the biocompatibility of the prepared nanocomposite hydrogel. It showed that the prepared nanocomposite hydrogel is non-toxic and can be used as a biocompatible wound dressing in practical wound management.

译文

在目前的工作中,使用有机改性的蒙脱土作为纳米粘土,以聚乙烯醇为基础,通过冻融循环法制备了纳米复合水凝胶伤口敷料。进行了体内测定,以评估其作为动物伤口敷料的性能。与无菌纱布覆盖的对照伤口相比,制备的纳米复合水凝胶覆盖的伤口的愈合过程得到了改善。显著的改善,例如在伤口上更好地形成潮湿的表面,更少的疤痕形成,更短的愈合手术时间和更好地闭合伤口边缘,增强愈合伤口的拉伸性能,即拉伸强度和断裂伸长率,与无菌纱布相比,使用制备的纳米复合水凝胶进行了观察。还利用体外细胞毒性测定法确定所制备的纳米复合水凝胶的生物相容性。结果表明,所制备的纳米复合水凝胶无毒,可作为生物相容性伤口敷料用于实际伤口处理。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录