In order to establish a human challenge model of Shigella related disease for vaccine testing, a dose-escalating inpatient trial was performed. Three groups of 12 healthy adult volunteers were orally challenged with 93,440 and 1680 CFU of Shigella sonnei strain 53G. Subjects were admitted to the Vaccine Trial Centre (VTC) at Mahidol University in Bangkok, Thailand. The primary purpose of this study was to identify the dose of S. sonnei 53G required to elicit clinical disease in at least 70% of Thai adult subjects. At the highest dose of 1680 CFU, the attack rate was 75%, while at the two lower doses, the attack rate was approximately 50%. This human challenge model, which is the first of its kind in an endemic region, will provide an opportunity for S. sonnei vaccine evaluation in endemic populations.

译文

为了建立志贺氏菌相关疾病的人类挑战模型以进行疫苗测试,进行了剂量递增的住院试验。用93,440和1680 CFU的宋内志贺氏菌53G口服攻击三组12名健康成人志愿者。受试者被送往泰国曼谷Mahidol大学的疫苗试验中心 (VTC)。这项研究的主要目的是确定至少70% 泰国成年受试者引起临床疾病所需的S. sonnei 53G剂量。在1680 CFU的最高剂量下,发作率为75%,而在两个较低剂量下,发作率约为50%。这种人类挑战模型是流行地区的同类模型中的第一个,它将为在流行人群中评估S. sonnei疫苗提供机会。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录