Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics.

译文

转化生长因子 β (tgf β) 控制多种细胞反应,包括增殖、分化、凋亡和迁移。这种细胞因子由许多不同的细胞类型产生,并与许多疾病的发病机理有关,从自身免疫性疾病和感染性疾病到纤维化和癌症。然而,tgf β 总是作为一种无活性的复合物产生,必须激活该复合物才能与其受体结合并随后发挥功能。最近的证据强调了整合素受体家族成员在控制tgf β 激活中的关键作用。这些途径在人类健康和疾病中很重要,并且对允许整联蛋白控制tgf β 活化的生化机制的新见解可能被证明对治疗方法的设计有用。

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