The TGFβ superfamily is composed of more than 33 growth and differentiation factors, including TGFβ1, β2, β3, BMPs, GDFs, nodal-related proteins, and activins. These members usually exert pleiotropic actions on several tissues and control multiple cellular processes, such as cell growth, cell survival, cell migration, cell fate specification, and differentiation, both during embryonic development and postnatal life. Although the effects of these factors on immune responses were elucidated long ago, most studies have been focused on the actions of TGFβs on T cells, as major regulators of adaptive immunity. In this review, we discuss new findings about the involvement of TGFβ superfamily members in the control of B cell development and function. Moreover, the potential contribution of TGFβ signaling to control B cell-mediated autoimmune diseases and its utility in the design of new therapies are also discussed.

译文

tgf β 超家族由超过33个生长和分化因子组成,包括TGFβ1,β2,β3,BMPs,GDFs,节点相关蛋白和激活素。这些成员通常在几个组织上发挥多效性作用,并控制多个细胞过程,例如胚胎发育和出生后的细胞生长,细胞存活,细胞迁移,细胞命运规范和分化。尽管这些因素对免疫反应的影响早已阐明,但大多数研究都集中在tgf β 对T细胞的作用上,作为适应性免疫的主要调节剂。在这篇综述中,我们讨论了有关tgf β 超家族成员参与控制b细胞发育和功能的新发现。此外,还讨论了tgf β 信号传导对控制b细胞介导的自身免疫性疾病的潜在贡献及其在设计新疗法中的效用。

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