Alternative splicing regulation has been shown to be critically important for several developmental pathways. It is particularly prevalent in the testis, which is the site of an extensive adult developmental programme. Alternative splicing is controlled by a splicing code, in which transcripts respond to subtle cell type-specific variations in positive and negative trans-acting RNA-binding proteins according to their unique set of binding sites for these proteins. Because of their unique combinations of cis-acting sequence elements, specific transcripts are able to respond individually to this code. In this review, we discuss how this code may be deciphered in germ cells to mediate a splicing response.

译文

替代剪接调节已被证明对几种发育途径至关重要。它在睾丸中特别普遍,睾丸是广泛的成人发育计划的场所。选择性剪接由剪接代码控制,其中转录本根据其独特的结合位点集,对阳性和阴性反式作用RNA结合蛋白的细微细胞类型特异性变化做出反应。由于顺式作用序列元素的独特组合,因此特定的转录本能够单独响应此代码。在这篇综述中,我们讨论了如何在生殖细胞中破译该代码以介导剪接反应。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录