The transverse decay of the arterial spin labeling (ASL) signal was measured at four inflow times in the rat brain cortex at 9.4 T. Biexponential T2 decay was observed that appears to derive from different T2 values associated with labeled water in the intravasculature (IV) and extravascular (EV) compartments. A two compartment biexponential model was used to assess the relative contribution of the IV and EV compartments to the ASL signal, without assuming a value for T2 of labeled blood water in the vessels. This novel methodology was applied to estimate the exchange time of blood water into EV tissue space and the oxygen saturation of blood on the arterial side of the vasculature. The mean exchange time of labeled blood water was estimated to be 370±40 ms. The oxygen saturation of the arterial side of the vasculature was significantly less than 100% (∼85%), which may have implications for quantitative functional magnetic resonance imaging studies where the arterial oxygen saturation is frequently assumed to be 100%.

译文

在9.4  T大鼠大脑皮层的四个流入时间测量动脉自旋标记 (ASL) 信号的横向衰减。观察到双指数T2衰减似乎源于与血管内 (IV) 和血管外 (EV) 隔室中标记水相关的不同T2值。使用两室双指数模型来评估IV和EV室对ASL信号的相对贡献,而无需假设血管中标记的血液水的T2值。这种新颖的方法用于估计血液水进入EV组织空间的交换时间以及脉管系统动脉侧血液的氧饱和度。标记血水的平均交换时间估计为370 ± 40  ms。脉管系统动脉侧的氧饱和度明显低于100% (~ 85%),这可能对定量功能磁共振成像研究有影响,其中动脉氧饱和度经常被认为是100% 的。

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