This study aimed to identify trends in bacteria isolated from Korean adults with chronic rhinosinusitis (CRS). Enrolled were CRS patients who underwent sinus bacterial culture during endoscopic sinus surgery between 2007-2008, 2011-2012, and 2017-2018 (n = 510). Patients' clinical characteristics, bacterial culture results, and antibiotic resistance were reviewed. The bacteria isolation rate was 76.3% (73.9% for CRS with nasal polyps and 82.8% for CRS without nasal polyps; p = 0.038). In total, 650 strains were isolated, the most common was Coagulase Negative Staphylococci (CNS) (28.0%), followed by Streptococcus species (12.2%), Propionibacterium species (8.0%), Corynebacterium species (7.5%), Staphylococcus aureus (6.2%), Haemophilus species (5.7%), Klebsiella species (5.1%), and Pseudomonas aeruginosa (4.2%). Furthermore, an analysis of the bacterial trends in the three groups showed significant increases over time for the isolation of CNS (p = 0.006), Klebsiella (p = 0.002), and P. aeruginosa (p = 0.007) and extended-spectrum beta-lactamase (ESBL) producing Klebsiella (p < 0.001) and Enterobacter (p = 0.007) species in terms of antibiotics resistance. This study demonstrates that the frequency of CNS, Klebsiella, and P. aeruginosa in CRS patients and the ESBL-producing Klebsiella and Enterobacter species has significantly increased in CRS patients over the last decade.

译文

这项研究旨在确定从患有慢性鼻鼻窦炎 (CRS) 的韩国成年人中分离出的细菌的趋势。纳入的CRS患者在2007-2008,2011-2012和2017-2018之间的内窥镜鼻窦手术期间接受了鼻窦细菌培养 (n = 510)。回顾了患者的临床特征,细菌培养结果和抗生素耐药性。细菌隔离率为76.3% (具有鼻息肉的CRS 73.9%,无鼻息肉的CRS 82.8%; p = 0.038)。共分离出650株,最常见的是凝固酶阴性葡萄球菌 (CNS) (28.0%),其次是链球菌 (12.2%) 、丙酸杆菌 (8.0%) 、棒状杆菌 (7.5%) 、金黄色葡萄球菌 (6.2%) 、嗜血杆菌 (5.7%) 、克雷伯菌 (5.1%),和铜绿假单胞菌 (4.2%)。此外,对三组细菌趋势的分析显示,随着时间的推移,CNS的分离显着增加 (p = 0.006),克雷伯菌 (p = 0.002),铜绿假单胞菌 (P = 0.007) 和产超广谱 β-内酰胺酶 (ESBL) 的克雷伯菌 (p < 0.001) 和肠杆菌 (p = 0.007) 对抗生素的耐药性。这项研究表明,在过去的十年中,CRS患者中CNS,克雷伯菌和铜绿假单胞菌的频率以及产生ESBL的克雷伯菌和肠杆菌的频率显着增加。

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