Mesial temporal lobe epilepsy (mTLE) is a neurological condition characterized by the occurrence of spontaneous recurrent seizures originating from mesial structures involving the hippocampus within the temporal lobe. This condition is often associated with pathological features in the hippocampus such as neuronal cell loss, widening of the granule cell layer, astrogliosis and mossy fibre spouting. At present, the mechanisms underlying these pathological features are unclear. However, recent advances in adult neurogenesis studies in mTLE animals and patients suggest that newly generated neurons may contribute to the pathogenesis of ongoing epileptogenesis. This article will review the recent animal and human studies on adult neurogenesis in mTLE and discuss how these results suggests that adult endogenous neurogenesis may not always be reparative in the mTLE and may be targeted in new therapeutic strategies for mTLE.

译文

颞叶内侧癫痫 (mTLE) 是一种神经系统疾病,其特征是发生自发性复发性癫痫发作,起源于颞叶内海马的内侧结构。这种情况通常与海马的病理特征有关,例如神经元细胞丢失,颗粒细胞层变宽,星形胶质细胞增生和苔藓状纤维喷出。目前,这些病理特征的机制尚不清楚。然而,在mTLE动物和患者中进行的成人神经发生研究的最新进展表明,新生的神经元可能有助于正在进行的癫痫发生的发病机理。本文将回顾最近有关mTLE中成人神经发生的动物和人类研究,并讨论这些结果如何表明成人内源性神经发生可能并不总是在mTLE中修复,并且可能在mTLE的新治疗策略中靶向。

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