Insulin quality and efficacy determine glycemic control, which determines quality of life for people with diabetes. Insulin efficacy is reduced by heat exposure, especially in tropical climates, remote areas, and with improper handling. Insulin doses can be adjusted based on blood glucose monitoring, which may compensate for lack of viability. However, a measured response may be difficult with other biopharmaceuticals. Thermochromic vial monitor technology developed for oral polio vaccines (vaccine vial monitors) is an inexpensive, easily available, visible modality which can be used for insulin and other biopharmaceuticals to detect excessive heat exposure and thus reduced potency at any point in the cold-chain, till the end-users, thus improving patient care. Regulatory authorities must urgently consider the need to impose mandatory use of this technology for all biopharmaceuticals, including insulin, to ensure efficacy till end usage.

译文

胰岛素质量和疗效决定血糖控制,血糖控制决定糖尿病患者的生活质量。暴露于热,尤其是在热带气候,偏远地区以及处理不当,会降低胰岛素的功效。可以根据血糖监测来调整胰岛素剂量,这可能会弥补缺乏生存能力。然而,对于其他生物制药来说,测量出的反应可能是困难的。为口服脊髓灰质炎疫苗开发的热致变色小瓶监测技术 (疫苗小瓶监测) 是一种廉价,易于获得,可见的方式,可用于胰岛素和其他生物制药,以检测过多的热暴露,从而降低在冷链中的任何点的效力,直到最终用户,从而改善病人护理。监管机构必须紧急考虑对包括胰岛素在内的所有生物制药强制使用该技术的必要性,以确保直至最终使用的有效性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录