Dapsone syndrome or sulphone syndrome was noticed within four to six weeks of starting treatment in 10 out of 604 patients (1.6%) on MDT for leprosy treated at Rajah Muthiah Medical College Hospital, South Arcot District, Tamil Nadu State during the period 1995-1998. Patients developed either maculo papular rash or exfoliation along with fever and lymphadenopathy. Abnormal liver function tests were noticed in 50%. The patients with dapsone syndrome were treated with corticosteriods after withdrawing dapsone. There was complete resolution of skin lesions and other symptoms.

译文

在1995-1998年期间,泰米尔纳德邦南阿科特区拉贾穆西亚医学院医院接受麻风病治疗的604名患者中有10名 (1.6% 名) 在开始治疗后的4至6周内发现了氨苯砜综合征或磺胺综合征。患者出现斑疹丘疹或剥脱以及发热和淋巴结肿大。50% 发现肝功能异常。氨苯砜综合征患者在撤回氨苯砜后接受皮质类固醇治疗。皮损和其他症状完全缓解。

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