Thirty factory workers whose annual exposure to TDI amounted to 280 hours were examined. Seven of them had been removed from their jobs for presenting respiratory symptomatology and a further five were removed for presenting bronchial asthma. Their medical histories were consulted and further measures were taken such as a radiological thorax study, total IgE, TDI, MDI and HDI RAST, a basal spirometric study and finally a provocation test. The Rast proved negative in every case. In the spirometric study carried out on the provocation test, four cases showed a significant decrease in the FEV1 over 20% and over 40% in the FMEF and PEFR. There was no connection between the four patients who presented an elevated total IgE and the four who presented a positive provocation test. The provocation test proved negative in five of the seven patients removed from their places of work. Two of the four workers who responded positively to the provocation test remained in their places of work during the TDI foam test without showing any symptoms. The patients who presented symptoms did not appear to present bronchial obstruction during the provocation test. Nonetheless, patients who seemingly had not shown any symptoms presented what appeared to be bronchial obstruction.

译文

检查了30名工厂工人,他们每年接触TDI达280小时。其中有7人因出现呼吸症状而被撤职,另有5人因出现支气管哮喘而被撤职。查阅了他们的病史,并采取了进一步的措施,例如放射学胸部研究,总IgE,TDI,MDI和HDI RAST,基础肺活量研究,最后是激发试验。Rast在每种情况下都被证明是否定的。在对激发试验进行的肺活量测定研究中,有4例显示FEV1随20% 和FMEF和PEFR随40% 而显着降低。总IgE升高的四名患者与激发试验阳性的四名患者之间没有联系。在离开工作场所的七名患者中,有五名被证明是阴性的。对挑衅测试做出积极反应的四名工人中有两名在TDI泡沫测试期间仍留在工作地点,没有出现任何症状。在激发试验中出现症状的患者似乎没有出现支气管阻塞。尽管如此,似乎没有表现出任何症状的患者似乎出现了支气管阻塞。

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