Interferon-tau (IFN-tau) is a type I IFN originally discovered for its role as a pregnancy recognition hormone in ruminant animals such as sheep and cows. IFN-tau possesses all of the biological properties ascribed to the other type I IFNs including antiviral, antiproliferative and immunomodulatory activities. However, IFN-tau differs in that it is relatively nontoxic to cells at high concentrations as compared to the toxicity normally associated with IFNs-alpha and -beta and the type II IFN, IFN-gamma. IFN-tau was examined for its ability to prevent the development of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), in humans. IFN-tau prevents development of EAE as effectively as IFN-beta, a type I IFN currently being used for the treatment of MS. Unlike IFN-beta, however, IFN-tau treated mice did not develop leucopenia or experience bodyweight loss indicative of toxicity. Superantigens can induce relapses in EAE, similar to those that are observed in patients with relapsing-remitting MS; IFN-tau blocks superantigen reactivation of EAE. The inhibitory effect of IFN-tau on induction of EAE and reactivation by superantigen involves suppression of myelin basic protein and superantigen activation of T cells as well as suppressed induction of inflammatory cytokines such as tumour necrosis factor-alpha. In addition, IFN-tau has been shown to reduce immunologically mediated spontaneous fetal resorption. Thus, IFN-tau has considerable potential for treatment of autoimmune and immunologically mediated disorders, including MS.

译文

干扰素-tau (IFN-tau) 是一种I型IFN,最初因其在反刍动物 (如绵羊和牛) 中作为妊娠识别激素而被发现。IFN-tau具有归因于其他I型IFN的所有生物学特性,包括抗病毒,抗增殖和免疫调节活性。然而,IFN-tau的不同之处在于,与通常与IFNs-α 和-β 以及II型IFN,IFN-γ 相关的毒性相比,它对高浓度的细胞相对无毒。检查了IFN-tau预防人类实验性过敏性脑脊髓炎 (EAE) (一种多发性硬化症 (MS) 的动物模型) 发展的能力。IFN-tau与IFN-β 一样有效地防止EAE的发展,IFN-β 是目前用于治疗MS的I型IFN。然而,与IFN-β 不同,IFN-tau处理的小鼠不会出现白细胞减少症或出现表明毒性的体重下降。超抗原可以诱导EAE的复发,类似于在复发缓解型MS患者中观察到的复发; IFN-tau阻断EAE的超抗原再激活。IFN-tau对EAE诱导和超抗原再激活的抑制作用涉及抑制髓磷脂碱性蛋白和T细胞的超抗原激活,以及抑制炎性细胞因子 (例如肿瘤坏死因子-α) 的诱导。此外,已显示IFN-tau可减少免疫介导的胎儿自发吸收。因此,IFN-tau在治疗自身免疫和免疫介导的疾病 (包括MS) 方面具有相当大的潜力。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录