Depression is one of the prevalent psychiatric illnesses with a comprehensive performance such as low self-esteem, lack of motivation, anhedonia, poor appetite, low energy, and uncomfortableness without a specific cause. So far, the cause of depression is not very clear, but it is certain that many aspects of biological psychological and social environment are involved in the pathogenesis of depression. Recently, the prefrontal cortex (PFC) has been indicated to be a pivotal brain region in the pathogenesis of depression. And increasing evidence showed that the abnormal activity of the PFC neurons is linked with depressive symptoms. Unveiling the molecular and cellular, as well as the circuit properties of the PFC neurons will help to find out how abnormalities in PFC neuronal activity are associated with depressive disorders. In addition, concerning many antidepressant drugs, in this review, we concluded the effect of several antidepressants on PFC neuronal activity to better understand its association with depression.

译文

抑郁症是一种普遍的精神疾病,具有全面的表现,例如自尊心低,缺乏动力,缺乏食欲,食欲差,精力不足和不舒适而没有特定原因。到目前为止,抑郁症的病因尚不十分清楚,但可以肯定的是,抑郁症的发病机制涉及了生物学心理和社会环境的诸多方面。最近,前额叶皮层 (PFC) 已被证明是抑郁症发病机理中的关键大脑区域。越来越多的证据表明,PFC神经元的异常活动与抑郁症状有关。揭示PFC神经元的分子和细胞以及电路特性将有助于发现PFC神经元活动异常如何与抑郁症相关。此外,关于许多抗抑郁药,在这篇综述中,我们得出了几种抗抑郁药对PFC神经元活性的影响,以更好地了解其与抑郁症的关系。

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