The cutaneous manifestations of autoimmune diseases, including systemic lupus erythematosus, are common and often recalcitrant to treatment. Unfortunately, therapy for lupus and other autoimmune skin diseases has not advanced and relies heavily on the use of oral and topical corticosteroids. Frequently, treatments prove less than ideal, either from toxicity or lack of efficacy. A topical form of the immunomodulating transplant medication, tacrolimus (FK-506, Protopic), has recently been developed and approved for use in treating atopic dermatitis. Its mechanism of action and local route of administration render tacrolimus a potentially attractive novel therapeutic alternative for the treatment of various autoimmune dermatologic conditions. We report our successful experience using this drug in 3 patients with autoimmune dermatologic disease who were referred to a tertiary care subspecialty clinic.

译文

自身免疫性疾病 (包括系统性红斑狼疮) 的皮肤表现是常见的,并且经常难以治疗。不幸的是,狼疮和其他自身免疫性皮肤病的治疗尚未进展,严重依赖于口服和局部皮质类固醇的使用。通常,无论是毒性还是缺乏疗效,治疗都不理想。最近开发了一种局部形式的免疫调节移植药物他克莫司 (FK-506,Protopic),并批准用于治疗特应性皮炎。他克莫司的作用机制和局部给药途径使他克莫司成为治疗各种自身免疫性皮肤病的潜在有吸引力的新型治疗选择。我们报告了我们在3例自身免疫性皮肤病患者中使用这种药物的成功经验,这些患者被转诊到三级护理亚专科诊所。

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