Protection against intracellular pathogens or tumor antigens requires T-cell mediated responses. Recently, it has become apparent that protection against disease correlates with T cells of the central memory type in many instances. Here, we analyze current data to distill a set of rules for the induction and maintenance of central memory T-cell responses. Recent studies show that T-cell help and the lack of overt inflammation at the time of priming are prerequisite for the induction, maintenance and expansion of memory T cells. Central to our hypothesis is that, in addition to these factors, successful vaccination in the immunologically inexperienced individual should be based on low antigen dose, to decelerate replicative senescence in responding cells and favor lineage differentiation of central memory T cells. In the immunologically experienced individual, it will be necessary, in addition, to abate the antigen load in plasma before vaccination. These guiding principles might help to raise improved protective T-cell responses by vaccination in humans.

译文

针对细胞内病原体或肿瘤抗原的保护需要T细胞介导的反应。最近,很明显,在许多情况下,对疾病的保护与中央记忆类型的T细胞有关。在这里,我们分析当前数据以提取用于诱导和维持中央记忆T细胞响应的一组规则。最近的研究表明,T细胞的帮助和在启动时缺乏明显的炎症是诱导,维持和扩增记忆T细胞的前提。我们的假设的核心是,除了这些因素外,免疫无经验个体的成功疫苗接种应基于低抗原剂量,以减缓应答细胞中的复制性衰老并有利于中央记忆T细胞的谱系分化。在具有免疫经验的个体中,有必要在接种疫苗之前减轻血浆中的抗原负荷。这些指导原则可能有助于通过人类疫苗接种提高保护性T细胞反应。

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