There is an abundance of clinical applications using human umbilical cord blood (HUCB) as a source for stem cell populations. Other than haematopoietic progenitors, there are mesenchymal, endothelial stem cells and neuronal precursors, in varying quantities, that are found in human umbilical cord blood. These may be useful in diseases such as immune deficiency and autoimmune disorders. Considering issues of safety, availability, transplant methodology, rejection and side effects, it is contended that a therapeutic stem cell transplant, utilizing stem cells from HUCB, provides a reliable repository of early precursor cells that can be useful in a great number of diverse conditions. Drawbacks of relatively smaller quantities of mononucleated cells in one unit of cord blood can be mitigated by in-vitro expansion procedures, improved in-vivo signalling, and augmentation of the cellular milieu, while simultaneously choosing the appropriate transplantation site and technique for introduction of the stem cell graft.

译文

使用人脐带血 (HUCB) 作为干细胞种群的来源有很多临床应用。除造血祖细胞外,在人脐带血中还发现了各种数量的间充质,内皮干细胞和神经元前体。这些可能在诸如免疫缺陷和自身免疫性疾病等疾病中有用。考虑到安全性,可用性,移植方法,排斥反应和副作用等问题,有人认为,利用HUCB干细胞的治疗性干细胞移植提供了可靠的早期前体细胞储存库,可用于多种多样的条件。可以通过体外扩增程序,改善体内信号传导和增加细胞环境,同时选择合适的移植部位和技术来引入脐带血,减轻脐带血中相对较少数量的单核细胞的缺点。干细胞移植物。

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