Clinical trials have demonstrated improved outcomes with cardiac resynchronization therapy in patients with heart failure and electrical evidence of dyssynchrony. There has been intense effort at developing imaging markers of dyssynchrony with the aim of improved risk stratification. However, these efforts have not been fruitful to date. This article discusses mechanisms of cardiac dyssynchrony, reviews clinical data supporting resynchronization therapy, and addresses the lack of convincing evidence to support the use of noninvasive imaging measures of dyssynchrony in improving patient management.

译文

临床试验表明,心脏再同步化治疗可改善心力衰竭和不同步电证据的患者的预后。为了改善风险分层,人们一直在努力开发不同步的成像标记物。然而,这些努力迄今没有取得成果。本文讨论了心脏不同步的机制,回顾了支持再同步化治疗的临床数据,并解决了缺乏令人信服的证据来支持使用不同步的非侵入性成像措施来改善患者管理的问题。

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