Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.

译文

帕金森氏病和其他一些神经退行性疾病与一种蛋白质有关,这种蛋白质可以聚集并形成称为 α-突触核蛋白的原纤维。与许多其他与神经退行性疾病相关的蛋白质一样,这种蛋白质没有已知的功能,并且它可能引起疾病的机制尚不明确。最近有人建议它结合铜。这篇评论评估了有关 α-突触核蛋白及其与金属相互作用的已知信息。

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