The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.

译文

寻找帕金森氏病 (PD) 的生物标志物导致描述生物流体和活检/尸检组织中外周 α-突触核蛋白 (aSyn) 的文献激增。尽管取得了令人鼓舞的结果,但利用这一诺言的尝试却远远不够。系统性突触核蛋白采样研究 (S4) 的独特设计,以确定可重复的PD诊断和进展生物标志物。S4将评估同一受试者内和整个疾病谱中的多个组织和生物流体中的aSyn,以确定最佳生物标志物来源,并提供有关整个疾病中周围aSyn演变的重要信息。此外,S4将全身性aSyn谱与黑质纹状体多巴胺能功能的客观测量相关联,以进一步了解PD的病理生理进展。

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