Deposition of alpha-synuclein (alphaS) aggregates inside brain cells is a pathological hallmark of several neurodegenerative diseases, including Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Recently, extracellular alphaS was detected in cerebrospinal fluid (CSF) and plasma of humans. We investigated whether CSF influences alphaS aggregation in vitro using fluorescence spectroscopy with thioflavin S and electron microscopy. We found that CSF obtained from Alzheimer's disease (AD) and DLB patients enhanced the alphaS fibril formation compared with tauopathy and non-central nervous system disease. Thus, CSF of AD and DLB characterized by aggregation of Abeta or alphaS might promote falphaS formation.

译文

脑细胞内 α-突触核蛋白 (alpha) 聚集体的沉积是几种神经退行性疾病的病理标志,包括帕金森氏病 (PD) 和路易体痴呆 (DLB)。最近,在人类的脑脊液 (CSF) 和血浆中检测到细胞外alpha。我们使用硫黄素S的荧光光谱法和电子显微镜研究了CSF是否会影响alpha的体外聚集。我们发现,与tauopathy和非中枢神经系统疾病相比,从阿尔茨海默氏病 (AD) 和DLB患者获得的CSF增强了alpha原纤维的形成。因此,以Abeta或alpha聚集为特征的AD和DLB的CSF可能会促进falpha的形成。

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