Extraction of pharmacologically active ingredient of ferulic acid from the root of Angelica sinensis with supercritical CO2 was investigated. The experimental results show that the extract yields were 0.87-4.06% at temperatures from 45 to 65 degrees Celsius and pressures from 30 to 50 MPa, and the maximum content of ferulic aicd in the extracts was about 0.35-0.37%, which is lower than that of 0.61-0.85% by conventional percolation methods. Ethanol was used as co-solvent in different ratios to raw materials in order to increase the content of ferulic acid in the extracts. The experimental results show that both the extract yields and the content of ferulic acid in the extracts increase greatly compared with pure CO2 extraction. When the ratio of ethanol to the raw material was 1.6, the content of ferulic acid in the extracts was 0.91-1.27%, indicating that supercritical fluid extraction (SFE) with CO2 in the presence of suitable co-solvent is superior to percolation in extracting polar ferulic acid from Angelica sinensis.
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【Extraction of ferulic acid from Angelica sinensis with supercritical CO2.].
【超临界co2萃取当归中阿魏酸的研究】
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DOI：10.1080/14786410500462579文章类型：杂志文章
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研究了超临界CO2从当归根中提取阿魏酸的药理活性成分。实验结果表明，在45 ~ 65摄氏度的温度和30 ~ 50 MPa的压力下，提取液的收率为0.87 ~ 4.06%，提取液中阿魏酸aicd的最大含量约为0.35 ~ 0.37%，低于常规渗滤法的0.61 ~ 0.85%。以不同的原料比例使用乙醇作为助溶剂，以增加提取物中阿魏酸的含量。实验结果表明，与纯CO2萃取相比，提取物的收率和提取物中阿魏酸的含量均大大提高。当乙醇与原料的比例为1.6时，提取物中阿魏酸的含量为0.91-1.27%，表明在合适的共溶剂存在下用CO2进行超临界流体萃取 (SFE) 在从当归提取极性阿魏酸时优于渗滤。
