Ammonium salts of some anions decrease the potency of glycine in inhibiting (3H)strychnine binding associated with synaptic glycine receptors. A correspondence exists between the ability of the ammonium salts of anions to increase the IC50 of glycine in inhibiting the (3H) strychnine binding, their capacity to reduce the (3H) strychnine binding itself, and their capacity to reverse inhibitory postsynaptic potentials. The decrease of (3H)strychnine binding in the presence of chloride is abolished by sodium, while the decrease of the potency of glycine in inhibiting (3H)strychnine is not. Binding of (3H)strychnine is influenced by monovalent cations in a biphasic fashion. Concentrations of Li+, K+, and Na+ up to 150mM decrease (3H)strychnine binding, while higher concentrations of the cations increase (3H)strychnine binding. Inhibition by glycine of (3H)strychnine binding is enhanced by low concentrations of these cations.

译文

某些阴离子的铵盐降低了甘氨酸抑制 (3H) 与突触甘氨酸受体相关的士的宁结合的效力。阴离子的铵盐增加甘氨酸抑制 (3H) 士的宁结合的IC50的能力之间存在对应关系,它们降低 (3H) 士的宁结合本身的能力,以及它们逆转抑制性突触后电位的能力。在氯化物存在下,(3H) 士的宁结合的减少被钠消除,而甘氨酸抑制 (3H) 士的宁的效力没有降低。(3H) 士的宁的结合受一价阳离子的双相影响。Li + 、K + 和Na + 的浓度高达150毫米会降低 (3H) 士的宁的结合,而较高浓度的阳离子会增加 (3H) 士的宁结合。低浓度的阳离子会增强甘氨酸对 (3H) 士的宁结合的抑制作用。

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