The paper describes the effect of different thermal treatments on the morphology and binding properties of particles prepared using a transacylation reaction between two biocompatible polymers, namely propylene glycol alginate and human serum albumin. Compared to control alginate gel microspheres, albumin-alginate covalent network offers a better resistance to the microspheres towards freezing, lyophilization and sterilization. The binding properties for methylene blue were not altered by the treatments. Moreover, stability in physiological environments opens interesting applications in biological and pharmaceutical fields.

译文

本文描述了不同热处理对使用两种生物相容性聚合物 (海藻酸丙二醇和人血清白蛋白) 之间的烷基转移反应制备的颗粒的形态和结合性能的影响。与对照藻酸盐凝胶微球相比,白蛋白-藻酸盐共价网络对微球的冷冻,冻干和灭菌具有更好的抵抗力。处理不会改变亚甲基蓝的结合特性。此外,生理环境中的稳定性在生物和制药领域开启了有趣的应用。

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