Bilateral synchronous epileptiform discharges registered in patients with partial epilepsies may be generated by different pathophysiological mechanisms. Differentiation between underlying mechanisms is often crucial for correct diagnosis and adequate treatment in clinical epileptology. The aim of this study was to model in rats two possible mechanisms--secondary bilateral sychrony and interaction between multiple epilepic foci. Furthermore, to describe in detail semiology, laterality and differences in motor phenomena. Secondary bilateral synchrony was modeled by unilateral topical application of bicuculline methiodide (BMI) over the sensorimotor cortex. Bilateral symmetric application of BMI was used as a model of multiple epileptic foci. Electrographic and behavioural phenomena were recorded for 1h following the application of BMI. Electroencephalogram in both groups was characterized by presence of bilateral synchronous discharges. Myoclonic and clonic seizures involving forelimb and head muscles represented the most common motor seizure pattern in both groups. Significant differences were found in the laterality of motor phenomena. Motor seizures in unilateral foci always started in the contralateral limbs whereas symmetrical foci exhibited bilateral independent onset of convulsions. Similar lateralization was observed in interictal motor phenomena (myoclonic jerks). An important influence of posture on epileptic motor phenomena was demonstrated. Active or passive changes in animal posture (verticalization to bipedal posture) caused conversion from unilateral myoclonic jerks or clonic seizures to bilaterally synchronous (generalized) motor phenomena in both groups.

译文

部分性癫痫患者的双侧同步癫痫样放电可能是由不同的病理生理机制产生的。潜在机制之间的区分对于临床表皮病的正确诊断和适当治疗通常至关重要。这项研究的目的是在大鼠中建立两种可能的机制-继发性双侧粘连和多个表位灶之间的相互作用。此外,要详细描述符号学,偏侧性和运动现象的差异。次级双侧同步性是通过在感觉运动皮层上单方面局部应用双苏氨酸甲碘化物 (BMI) 来模拟的。双侧对称应用BMI被用作多个癫痫灶的模型。应用BMI后1小时记录了电学和行为现象。两组的脑电图均以双侧同步放电为特征。涉及前肢和头部肌肉的肌阵挛和阵挛性癫痫发作是两组中最常见的运动癫痫发作模式。在运动现象的偏侧性方面发现了显着差异。单侧病灶的运动性癫痫发作总是在对侧肢体开始,而对称性病灶表现出双侧独立的抽搐发作。在发作间运动现象 (肌阵挛抽搐) 中观察到类似的偏侧化。证明了姿势对癫痫运动现象的重要影响。动物姿势的主动或被动变化 (垂直化为两足姿势) 导致两组患者从单侧肌阵挛抽搐或阵挛性癫痫发作转变为双侧同步 (广义) 运动现象。

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