Hypertension and hyperlipidemia, two powerful risk factors of cardiovascular disease (CVD), often coexist. Therefore, treatment should consider the beneficial properties of drugs used to treat either condition. Statins, the mainstay of lipid-lowering therapy, result in a significant clinical benefit both in primary and secondary CVD prevention. In addition to their hypolipidemic capacity, other properties may contribute to statin-induced benefits. Clinical and experimental evidence indicates that statins may modulate blood pressure (BP). The mechanisms by which statins reduce BP seem to be largely independent of their lipid effects. Although small, reductions in BP are possibly clinically relevant. Large landmark studies confirm that statins can reduce CVD risk in hypertensive patients. These findings suggest that statins could be prescribed as an adjunct in treating hypertension with dyslipidemia or even in patients with "normal" cholesterol levels. Whether the effect of statins on BP is accompanied by an additional decrease in clinical outcomes needs to be investigated in long-term, large-scale trials.

译文

高血压和高脂血症是心血管疾病 (CVD) 的两个重要危险因素,通常并存。因此,治疗应考虑用于治疗任何一种疾病的药物的有益特性。他汀类药物是降脂治疗的主要手段,在原发性和继发性CVD预防中均具有显着的临床益处。除了降血脂能力外,其他特性可能有助于他汀类药物诱导的益处。临床和实验证据表明,他汀类药物可能调节血压 (BP)。他汀类药物降低血压的机制似乎在很大程度上与其脂质作用无关。尽管血压降低幅度很小,但可能与临床相关。大型标志性研究证实,他汀类药物可以降低高血压患者的CVD风险。这些发现表明,他汀类药物可以作为治疗血脂异常的高血压甚至胆固醇水平正常的患者的辅助药物。他汀类药物对血压的影响是否伴随着临床结局的额外降低,需要在长期的大规模试验中进行研究。

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