Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question.

译文

年龄相关性黄斑变性 (AMD) 是工业化国家65岁以上患者不可逆的中枢视力丧失的主要原因。流行病学研究表明,高饮食脂肪摄入量是血管和视网膜疾病发生和发展的危险因素。这些以及其他关联表明,胆固醇升高与AMD进展相关的假说。因此,降胆固醇药物,如他汀类药物,可能会影响AMD的发病和进展。然而,对于他汀类药物是否在AMD中发挥作用,研究结果尚无定论。由于他汀类药物对AMD发病和进展的潜在抑制作用对公共健康的重大影响,因此不断评估与该问题密切相关的新兴发现非常重要。

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