Selective serotonin reuptake inhibitors (SSRIs) are apt to cause gastrointestinal adverse events such as nausea and dyspepsia. Gorei-san (TJ-17), which is composed of five herbs (Alismatis rhizoma, Atractylodis lanceae rhizoma, Polyporus, Hoelen, and Cinnamomi cortex), is a Japanese herbal medicine that has been used to treat nausea, dry mouth, edema, headache, and dizziness. The authors investigated the efficacy of TJ-17 for patients who experienced nausea or dyspepsia induced by SSRIs. Twenty outpatients who experienced nausea or dyspepsia induced by SSRIs were recruited for the study. Seventeen patients were female, three were male, and patient age ranged from 21 to 74 years (49.8 +/- 17.0 years). TJ-17 was added to the previous regimen. Nausea and dyspepsia disappeared completely in nine patients, decreased in four patients, decreased slightly in two patients, and did not change in five patients. No adverse events were associated with the addition of TJ-17 in any patient.

译文

选择性5-羟色胺再摄取抑制剂 (SSRIs) 容易引起胃肠道不良事件,如恶心和消化不良。Gorei-san (TJ-17) 是一种日本草药,已用于治疗恶心,口干,水肿,头痛和头晕。作者研究了TJ-17对患有SSRIs引起的恶心或消化不良的患者的疗效。本研究招募了20名患有SSRIs引起的恶心或消化不良的门诊患者。17例患者为女性,3例为男性,患者年龄为21至74岁 (49.8 +/- 17.0岁)。将TJ-17添加到先前的方案中。9例患者恶心和消化不良完全消失,4例减少,2例略有减少,5例无变化。在任何患者中,没有与增加TJ-17相关的不良事件。

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