KT is the most effective therapeutic option for ESRF. We present our first experiences in a developing country. All children who underwent kidney transplantation since the inception of this program in July 2004 until 30 September 2005 were studied. Their demographic data, operative and peri-operative details, graft and host survival, and drug compliance are described here. Data were collected from patient records and nursing observation records. Eleven children were transplanted during this period (median recipient age 10.75 yr, range: 8-16). The median age of the donors was 41 yr (range: 38-45) and was the mother in eight, father in two and uncle in one. The median (range) follow-up period following transplantation was 12.5 months (7-12). The vascular anastomotic site was aorta and inferior vena cava in nine patients and the cold ischemia time was mean (s.d.) 1.9 h (0.96). All patients received steroids, cyclosporine and MMF for immunosuppression. Hypotension, heart failure and septicemia were common medical complications. Four were treated for acute rejection. Vascular anastomotic leak, burst abdomen, intestinal obstruction, intra-abdominal leak of supra pubic catheter and vesico-ureteric junction obstruction were surgical complications. There were no graft losses or deaths. Despite limited resources good outcomes are possible following renal transplantation in children in developing countries.

译文

KT是ESRF最有效的治疗选择。我们介绍了我们在发展中国家的第一次经历。研究了自2004年7月该计划启动以来直到2005年9月30日所有接受肾脏移植的儿童。此处描述了他们的人口统计数据,手术和围手术期详细信息,移植物和宿主存活率以及药物依从性。数据来自患者记录和护理观察记录。在此期间移植了11名儿童 (中位接受者年龄10.75岁,范围: 8-16岁)。捐赠者的平均年龄为41岁 (范围: 38-45岁),母亲为8岁,父亲为2岁,叔叔为1岁。移植后的中位 (范围) 随访期为12.5个月 (7-12)。9例患者的血管吻合部位为主动脉和下腔静脉,平均冷缺血时间 (s.d.)1.9 h (0.96)。所有患者均接受类固醇,环孢素和MMF进行免疫抑制。低血压、心力衰竭和败血症是常见的内科并发症。四例因急性排斥反应而接受治疗。血管吻合口漏,腹部爆裂,肠梗阻,耻骨上导管腹腔内漏和膀胱-输尿管交界处梗阻是手术并发症。没有移植损失或死亡。尽管资源有限,但在发展中国家的儿童进行肾移植后,仍有可能取得良好的结果。

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