The preparation of submicron-sized particles is relevant in chemical, food and pharmaceutical applications. In pharmaceutics, spray dried submicron-sized particles (0.1-1 µm) can increase the dissolution rate as well as the solubility of poorly water-soluble drugs. Since the particle size during spray drying is mainly influenced by the droplet size, the preparation of uniform droplets smaller than 3 µm is of particular interest. In this work, a two-fluid nozzle was combined with a cyclone droplet separator. Droplets larger than the cut-off size were separated with a cyclone droplet separator and returned to the liquid feed. The aerosol at the outlet of the droplet separator was subsequently dried. The drop size of the conditioned aerosol was small, d50,3=2 µm, and independent of the liquid-to-gas mass flow ratio and the viscosity of the liquid feed. Thus it only depended on the characteristics of the separator. Finally, the dried particles were spherical in shape and in the submicron-sized range.

译文

亚微米级颗粒的制备与化学,食品和制药应用有关。在药剂学中,喷雾干燥的亚微米级颗粒 (0.1-1 µm µ m) 可以增加溶解速率以及水溶性差的药物的溶解度。由于喷雾干燥过程中的粒径主要受液滴尺寸的影响,因此制备小于3 µ m的均匀液滴特别令人感兴趣。在这项工作中,将双流体喷嘴与旋风液滴分离器组合在一起。用旋风液滴分离器分离大于截止尺寸的液滴,然后返回液体进料。随后干燥液滴分离器出口处的气溶胶。经过调节的气溶胶的液滴尺寸较小,d50,3 = 2  µ m,并且与液气质量比和液体进料的粘度无关。因此,它仅取决于分离器的特性。最后,干燥的颗粒呈球形,并且在亚微米级范围内。

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