The aim of this prospective study was to compare the diagnostic role of superparamagnetic iron oxide (SPIO)-enhanced liver magnetic resonance imaging (MRI) versus gadobenate dimeglumine (GbD)-enhanced MRI and computed tomography (CT) investigations for detection of small (less than 1cm) colorectal liver metastases (LMs) of colorectal cancer. Seventy-eight LMs in 16 patients were evaluated with dynamic CT imaging, GbD-enhanced dynamic MR imaging and SPIO-enhanced MR imaging. Two radiologists were reviewed the LMs separately. Agreement between the readers and three algorithms was analyzed. Differences between the lesion detection ratios of the methods were analyzed by two proportion z test. Sensitivity values of each modality were also calculated. Interobserver agreement values with kappa analysis were found to be the best for three modalities and kappa values were 0.866, 0.843, and 1.0 respectively. For all 78 LMs, SPIO-enhanced MRI detected all lesions (100% sensitivity). This sensitivity value was higher than GbD-enhanced MRI, and there was a significant difference (p < 0.05). GbD-enhanced MRI depicted 71 lesions and this modality could not detected 7 lesions (91% sensitivity). This modality had moderate sensitivity, and this value is greater than CT imaging, so there was a significant difference also (p < 0.05). Dynamic triphasic CT imaging detected 64 (R1) and 65 (R2) LMs. This modality had the lowest sensitivity (R1: 0.82, R2: 0.83 respectively). Only SPIO-enhanced MRI was able to detect all LMs less than 1cm. LMs were the best detected with SPIO-enhanced MRI. We recommend SPIO-enhanced MRI to be the primary alternative modality especially for diagnosis of small colorectal LMs.

译文

这项前瞻性研究的目的是比较超顺磁性氧化铁 (SPIO) 增强的肝脏磁共振成像 (MRI) 与加多本酸二甲胺 (GbD) 增强的MRI和计算机断层扫描 (CT) 检查在检测小 (小于1厘米) 结直肠肝转移 (LMs) 中的诊断作用结直肠癌。对16例患者的78例LMs进行了动态CT成像,GbD增强的动态MR成像和SPIO增强的MR成像评估。两名放射科医生分别接受了LMs检查。分析了读者与三种算法之间的一致性。通过两个比例z检验分析了方法的病变检测率之间的差异。还计算了每种模式的灵敏度值。发现具有kappa分析的观察者间一致性值对于三种模式是最佳的,并且kappa值分别为0.866,0.843和1.0。对于所有78个LMs,SPIO增强MRI检测到所有病变 (100% 敏感性)。该灵敏度值高于GbD增强MRI,差异有统计学意义 (p <0.05)。GbD增强的MRI描绘了71个病变,并且这种方式无法检测到7个病变 (91% 敏感性)。这种模式具有中等敏感性,并且该值大于CT成像,因此也存在显着差异 (p <0.05)。动态三相CT成像检测到64 (R1) 和65 (R2) LMs。该模态具有最低的灵敏度 (分别为R1: 0.82,R2: 0.83)。只有SPIO增强的MRI能够检测到小于1厘米的所有LMs。用SPIO增强MRI检测到LMs最好。我们建议SPIO增强MRI是主要的替代方式,尤其是对于小结直肠LMs的诊断。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录