This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of superparamagnetic iron oxide (SPIO) contrast agent. The R2* and proton density fat fraction (PDFF) were measured in liver and spine in 14 subjects using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made before and after SPIO infusion. Results showed SPIO significantly increased R2* in both liver (p=8.8×10(-8)) and spine (p=1.3×10(-2)) but PDFFs were not significantly different in either the liver (p=5.5×10(-1)) or the spine (p=5.6×10(-1)). These results confirm that the IDEAL IQ method of fat quantification is robust to changes in R2*.

译文

这项研究评估了磁共振 (MR) 脂肪定量方法对静脉输注超顺磁性氧化铁 (SPIO) 造影剂引起的R2 * 变化的鲁棒性。使用MR扫描仪供应商提供的研究序列 (理想智商) 在14名受试者的肝脏和脊柱中测量R2 * 和质子密度脂肪分数 (PDFF)。在SPIO输注之前和之后进行测量。结果显示,SPIO在肝脏 (p = 8.8 × 10(-8)) 和脊柱 (p = 1.3 × 10(-2)) 中均显着增加R2 *,但PDFFs在肝脏 (p = 5.5 × 10(-1)) 或脊柱 (p = 5.6 × 10(-1))。这些结果证实了理想的IQ脂肪定量方法对R2 * 的变化是稳健的。

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