There has been recent interest in positive-contrast MRI methods for noninvasive tracking of cells labeled with superparamagnetic iron-oxide nanoparticles. Low-tip-angle balanced steady-state free precession sequences have been used for fast, high-resolution, and flow-insensitive positive-contrast imaging; however, the contrast can be compromised by the limited suppression of the on-resonant and fat signals. In this work, a new technique that produces positive contrast with alternating repetition time steady-state free precession is proposed to achieve robust background suppression for a broad range of tissue parameters. In vitro and in vivo experiments demonstrate the reliability of the generated positive contrast. The results indicate that the proposed method can enhance the suppression level by up to 18 dB compared with conventional balanced steady-state free precession.

译文

最近对正对比MRI方法进行非侵入性追踪用超顺磁性氧化铁纳米颗粒标记的细胞产生了兴趣。低尖端角度平衡的稳态自由进动序列已用于快速,高分辨率和对流动不敏感的正对比度成像; 但是,对共振和脂肪信号的有限抑制可能会损害对比度。在这项工作中,提出了一种通过交替重复时间稳态自由进动产生正对比的新技术,以实现对广泛组织参数的鲁棒背景抑制。体外和体内实验证明了产生的阳性对比的可靠性。结果表明,与传统的平衡稳态自由进动相比,该方法可以将抑制水平提高多达18 dB。

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