Aortic stiffness, an independent predictor of cardiovascular risk and all-cause mortality, can be estimated non-invasively by measuring carotid to femoral (aortic) pulse wave velocity (aPWV). The Vicorder device has been developed to measure aPWV with little operator training in a non-intrusive manner. The aim of this study was to assess the repeatability of aPWV measured with the Vicorder device and to compare aPWV values with those obtained using the SphygmoCor system. Vicorder and SphygmoCor aPWV was assessed in 122 subjects (53+/-18 years, 46 male) using both the manufacturers' and a standardized approach. Vicorder aPWV measurement proved to be highly repeatable (within-subject coefficient of variation 2.8%). Transit time differed significantly between the two devices (mean difference 22+/-9 ms, P<0.001), independent of the different algorithms used to calculate transit time. However, aPWV was similar between the two devices (mean difference 0.31+/-1.54 m s(-1), P<0.001) though with an inherent bias toward lower Vicorder aPWV values at high values of SphygmoCor aPWV. Bias was reduced by subtracting the additional femoral artery segment measured by the Vicorder device, also bringing the measure of transit time in closer agreement to SphygmoCor values (mean difference 5+/-9 ms, P<0.001). Transit time values significantly differed between the two devices and the Vicorder device reported lower aPWV values at higher SphygmoCor values of aPWV. This difference in transit time and inherent bias was reduced when adjustment for the additional femoral artery segment measured by the Vicorder device was made.

译文

:主动脉僵硬度是心血管风险和全因死亡率的独立预测因子,可以通过测量颈动脉至股动脉(主动脉)脉搏波速度(aPWV)进行无创估计。 Vicorder设备已被开发用于以非侵入性方式在很少的操作员培训的情况下测量aPWV。这项研究的目的是评估使用Vicorder设备测量的aPWV的可重复性,并将aPWV值与使用SphygmoCor系统获得的aPWV值进行比较。使用制造商的方法和标准化方法对122位受试者(53岁/ -18岁,男性46位)中的Vicorder和SphygmoCor aPWV进行了评估。 Vicorder aPWV测量被证明具有很高的可重复性(受试者内部变异系数为2.8%)。两个设备之间的传输时间显着不同(平均差异为22 / -9 ms,P <0.001),与用于计算传输时间的不同算法无关。然而,尽管在较高的SphygmoCor aPWV值下,固有的偏向于较低的Vicorder aPWV值,但两个设备之间的aPWV相似(平均差0.31 / 1.54 m s(-1),P <0.001)。通过减去由Vicorder设备测量的额外股动脉段来减少偏倚,也使通过时间的测量值与SphygmoCor值更加一致(平均差5 / -9 ms,P <0.001)。两个设备之间的传输时间值显着不同,Vicorder设备报告的aPWV的SphygmoCor值较高时,aPWV值较低。当对通过Vicorder设备测量的额外股动脉段进行调整时,运输时间和固有偏倚的差异减小了。

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