BACKGROUND:Arterial stiffness, measured as aortic pulse wave velocity (PWV), and wave reflection, measured as augmentation index (AIx), are independent predictors for total and cardiovascular morbidity and mortality. The aim of this study was to compare a new device, based on oscillometric pressure curves (Arteriograph), which simultaneously measures PWV and AIx, with standard techniques for measuring PWV (Complior) and AIx (SphygmoCor) in untreated hypertensive patients. METHODS:We compared PWV and AIx measured using the Arteriograph with corresponding Complior and SphygmoCor measurements in 254 untreated hypertensive patients, age 48 +/- 14 years (mean +/- SD, range 17-85 years). RESULTS:Arteriograph PWV and AIx were closely related with Complior (r = 0.60, P < 0.001) and SphygmoCor (r = 0.89, P < 0.001), respectively. Using stepwise regression analysis, the independent determinants of Arteriograph PWV were age, mean arterial pressure, heart rate and sex (r(2) = 0.44, P < 0.0001) and for AIx were age, weight, mean arterial pressure, heart rate and sex (r(2) = 0.65, P < 0.0001). The bias between the different techniques was determined by age and sex for PWV and age, body weight, sex, heart rate and mean arterial pressure for AIx. Bland-Altman plots showed that although the techniques were closely related, the limits of agreement were wide. CONCLUSION:Although Arteriograph values and the determinants of PWV and AIx are in close agreement with corresponding parameters obtained by Complior and SphygmoCor, respectively, the techniques are not interchangeable.

译文

背景:以主动脉脉搏波速度(PWV)衡量的动脉僵硬度和以增强指数(AIx)衡量的波反射是总和心血管发病率和死亡率的独立预测因子。这项研究的目的是比较一种基于示波压力曲线(动脉造影仪)的新设备,该设备可同时测量PWV和AIx,以及用于测量未经治疗的高血压患者的PWV(Complior)和AIx(SphygmoCor)的标准技术。
方法:我们比较了使用动脉造影仪测量的PWV和AIx以及相应的Complior和SphygmoCor测量值,对254位年龄在48岁至14岁(平均SD,范围17-85岁)的未经治疗的高血压患者进行了比较。
结果:动脉造影PWV和AIx分别与Complior(r = 0.60,P <0.001)和SphygmoCor(r = 0.89,P <0.001)密切相关。使用逐步回归分析,动脉造影PWV的独立决定因素是年龄,平均动脉压,心率和性别(r(2)= 0.44,P <0.0001),对于AIx,年龄,体重,平均动脉压,心率和性别是(r(2)= 0.65,P <0.0001)。不同技术之间的偏差由PWV的年龄和性别以及AIx的年龄,体重,性别,心率和平均动脉压确定。布兰德-奥特曼(Bland-Altman)图表明,尽管技术密切相关,但是一致的范围却很广。
结论:尽管动脉造影值和PWV和AIx的决定因素分别与Complior和SphygmoCor获得的相应参数紧密一致,但这些技术不可互换。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录