CD3(-)CD4(+)CD45(+) inducer cells are required for the initiation of mucosa-associated organogenesis of both nasopharynx-associated lymphoid tissues (NALT) and Peyer's patches (PP) in the aerodigestive tract. CXCL13(-/-) mice and mice carrying the paucity of lymph node T cell (plt) mutation and lacking expression of CCL19 and CCL21 accumulate CD3(-)CD4(+)CD45(+) cells at the site of NALT but not of PP genesis. Although NALT was observed to develop in adult CXCL13(-/-) and plt/plt mice, the formation of germinal centers in CXCL13(-/-) mice was affected, and their population of B cells was much lower than in the NALT of CXCL13(+/-) mice. Similarly, fewer T cells were observed in the NALT of plt/plt mice than in control mice. These findings indicate that the initiation of NALT organogenesis is independent of CXCL13, CCL19, and CCL21. However, the expression of these lymphoid chemokines is essential for the maturation of NALT microarchitecture.

译文

:CD3(-)CD4()CD45()诱导细胞是启动鼻咽相关淋巴样组织(NALT)和淋巴集结(PP)在消化道中黏膜相关器官发生的开始所必需的。 CXCL13(-/-)小鼠和携带淋巴结T细胞(plt)突变且缺乏CCL19和CCL21表达的小鼠在NALT部位积累了CD3(-)CD4()CD45()细胞,但没有PP发生。尽管观察到NALT在成年CXCL13(-/-)和plt / plt小鼠中发育,但是CXCL13(-/-)小鼠生发中心的形成受到影响,其B细胞数量远低于NALT的NALT。 CXCL13(/-)小鼠。同样,在plt / plt小鼠的NALT中观察到的T细胞少于对照小鼠。这些发现表明NALT器官发生的启动独立于CXCL13,CCL19和CCL21。但是,这些淋巴趋化因子的表达对于NALT微结构的成熟至关重要。

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